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Curcumin with Piperine

Due to a rapid increase in demand we have been able to negotiate a reduction in price from £29.99 to £19.99 for your benefit.

Clinical studies show curcumin is useful for the prevention & treatment of many "serious illnesses".  Curcumin with Piperine builds the immune system, is anti-tumor, antiarthritic, and anti-inflammatory*.

90 Caps

 

 

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£ 19.99

Curcumin — Has Biological and Medicinal Properties*

this is an extract that can be found on the internet as follows.

Molecules. 2014 Dec 24;20(1):185-205. doi: 10.3390/molecules20010185.

Curcumin differs from tetrahydrocurcumin for molecular targets, signaling pathways and cellular responses.

Author information

  • 1Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston 77054, TX, USA. aggarwal@mdanderson.org.
  • 2Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston 77054, TX, USA. lokeshdeb@gmail.com.
  • 3Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston 77054, TX, USA. spbiotech@gmail.com.

Abstract

Curcumin (diferuloylmethane), a golden pigment from turmeric, has been linked with antioxidant, anti-inflammatory, anticancer, antiviral, antibacterial, and antidiabetic properties. Most of the these activities have been assigned to methoxy, hydroxyl, α,β-unsaturated carbonyl moiety or to diketone groups present in curcumin. One of the major metabolites of curcumin is tetrahydrocurcumin (THC), which lacks α,β-unsaturated carbonyl moiety and is white in color. Whether THC is superior to curcumin on a molecular level is unclear and thus is the focus of this review. Various studies suggest that curcumin is a more potent antioxidant than THC; curcumin (but not THC) can bind and inhibit numerous targets including DNA (cytosine-5)-methyltransferase-1, heme oxygenase-1, Nrf2, β-catenin, cyclooxygenase-2, NF-kappaB, inducible nitric oxide synthase, nitric oxide, amyloid plaques, reactive oxygen species, vascular endothelial growth factor, cyclin D1, glutathione, P300/CBP, 5-lipoxygenase, cytosolic phospholipase A2, prostaglandin E2, inhibitor of NF-kappaB kinase-1, -2, P38MAPK, p-Tau, tumor necrosis factor-α, forkhead box O3a, CRAC; curcumin can inhibit tumor cell growth and suppress cellular entry of viruses such as influenza A virus and hepatitis C virus much more effectively than THC; curcumin affects membrane mobility; and curcumin is also more effective than THC in suppressing phorbol-ester-induced tumor promotion. Other studies, however, suggest that THC is superior to curcumin for induction of GSH peroxidase, glutathione-S-transferase, NADPH: quinone reductase, and quenching of free radicals. Most studies have indicated that THC exhibits higher antioxidant activity, but curcumin exhibits both pro-oxidant and antioxidant properties.

PMID:
 
25547723
 
[PubMed - in process] 
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Curcumin with Piperine

Curcumin with Piperine

Due to a rapid increase in demand we have been able to negotiate a reduction in price from £29.99 to £19.99 for your benefit.

Clinical studies show curcumin is useful for the prevention & treatment of many "serious illnesses".  Curcumin with Piperine builds the immune system, is anti-tumor, antiarthritic, and anti-inflammatory*.

90 Caps

 

 

Write your review